DEUBIQUITINATION OF EPIDERMAL GROWTH FACTOR RECEPTOR BY UBIQUITIN-SPECIFIC PEPTIDASE 54 ENHANCES DRUG SENSITIVITY TO GEFITINIB IN GEFITINIB-RESISTANT NON-SMALL CELL LUNG CANCER CELLS.

A precise balance between ubiquitination and deubiquitination is crucial for cellular regulation.Ubiquitin-specific peptidase 54 (USP54), an active deubiquitinase (DUB), modulates the ubiquitination of the epidermal growth factor receptor (EGFR).While the significance of USP54 Bed Rails in tumorigenesis is known, its specific function in cancer pro

Management of patients with back pain is an interdisciplinary problem requiring a package of diagnostic and differential measures.Despite the elaboration of algorithms for the differential diagnosis and therapy womens sports bra of back pain, a number of questions remain difficult to interpret, which can lead to diagnostic errors.This review consid

This paper reviews the existing studies employing total cost of ownership (TCO) analysis to evaluate the comparative economic viability of battery electric trucks (BETs) and diesel Daybed with Trundle trucks (DTs).A key finding is that until recent years, BETs have not been cost-competitive with DTs.Light-duty trucks and medium-duty trucks started

We highlight the importance of island research that aims to achieve sustainability transitions.All too often, developmental priorities are largely defined by Daybed with Trundle economic policy imperatives, and island research either ignores or masks such normative connotations.This article reports on ten years of transdisciplinary socioecological